Abstract
(1) The role of γ-aminobutyric acid (GABA) in the inhibition of synaptic transmission across the dorsal column nuclei was investigated in Nembutal-anesthetized, and unanesthetized decerebrate, cats. (2) Semicarbazide (200 mg/kg) produced a pronounced depression of the surface positive wave and the dorsal column reflex. It also reduced the prolonged (over 125 msec) increase in excitability of cuneate terminals, and the inhibition of the lemniscal response, induced by conditioning cutaneous nerve stimulation. (3) The time course of all these effects, which developed gradually over a 3–4 h period, correlated well with that of the depletion of GABA in the dorsal column nuclei. (4) Pyridoxine hydrochloride (200 mg/kg) antagonized all the effects of semicarbazide and returned GABA levels to near control values within 1 h. (5) GABA appears to play an important role in presynaptic inhibition of cuneate transmission. The possible mediation by GABA of both presynaptic and postsynaptic inhibition, partly through ‘bi-inhibitory’ cells, is discussed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
