Year-end Sale % OFF 
Abstract
1. Isolated lungs of the frog, Rana esculenta L., when incubated in amphibian Ringer solution for 30 min, produced a prostaglandin E 2-like substance (27.1 + 3.8 ng/g w.w.), as determined by bioassay on the isolated rat stomach strip. 2. The release of PGE 2-like substance from skin, heart and bowel is also reported. 3. The activity of synthetic prostaglandins E 2 (PGE 2 and F 2alpha (PGF 2alpha) on the muscular contractility of frog isolated lungs was investigated: PGE 2 and PGF 2alpha relaxed and contracted respectively in a dose-dependent manner this preparation, a result similar to that obtained in mammals.
Highlights
The antagonistic actions of PGE, and PGF,alpha on mammalian bronchial muscle have been shown by several investigators: as a rule PGF,alpha contracts, and PGEz relaxes preparations from numerous species, including man (Anggard and Bergstrom, 1963; Cuthbert and Gardiner, 1981)
The activity of synthetic prostaglandins E, (PGE,) and F,alpha (PGF,alpha) on the muscular contractility of frog isolated lungs was investigated: PGE, and PGF,alpha relaxed and contracted respectively in a dose-dependent manner this preparation, a result similar to that obtained in mammals
During a survey on the presence and biological activities of prostanoids on isolated smooth muscle preparations of lower vertebrates, it was noticed that the isolated lungs of the common frog (Rana esculenta L.) both produced PGE,like material and responded to PGE, and PGF,alpha in a fashion qualitatively identical to the one reported in mammals
Summary
ANTAGONISTIC ACTIONS OF PROSTAGLANDINS E, AND F, ALPHA ON THE ISOLATED LUNGS OF THE FROG, RANA ESCULENTA L. of Experimental Pharmacology, School of Pharmacy, University via L. Rodin 22, Naples, Italy 80138 of Naples,. Isolated lungs of the frog, Ram esculenfu L., when incubated in amphibian Ringer solution for 30 min, produced a prostaglandin E,-like substance I + 3.8 rig/g w.w.), as determined by bioassay on the isolated rat stomach strip. 2. The release of PGE,-like substance from skin, heart and bowel is reported. 3. The activity of synthetic prostaglandins E, (PGE,) and F,alpha (PGF,alpha) on the muscular contractility of frog isolated lungs was investigated: PGE, and PGF,alpha relaxed and contracted respectively in a dose-dependent manner this preparation, a result similar to that obtained in mammals
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Comparative Biochemistry and Physiology Part C: Comparative Pharmacology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
