Abstract
CERTAIN anterior pituitary preparations have been shown to reduce the response of the ovaries of immature rats to exogenous gonadotrophins. This antagonistic action was first associated with preparations rich in growth hormone (1) but was later demonstrated to be more closely associated with the LH (2, 3, 4) or with the FSH (4, 5). However, these experiments have been contradictory and the mechanism of antagonism is not understood. With the widespread use of gonadotrophins for therapeutic as well as experimental purposes a better understanding of this phenomenon would appear to be of value. The present study was designed to obtain additional knowledge of factors influencing the antagonistic action of FSH against ovarian stimulation produced by a homogenate of rat anterior pituitary glands (RPH). method and materials Animals. The albino rats used in this study were pen-bred in our laboratory from Wistar stock. Littermates, 21 to 23 days old, weighing 35 to 45 gm., were distributed equally among the control...
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