Abstract
The effect of 1-(2-pyrimidinyl)piperazine (PmP), the main metabolite of buspirone, was tested on K +-evoked [ 3H]noradrenaline and [ 3H]serotonin release from superfused synaptosomes obtained from rat cerebral cortex. PmP had no effects per se, but antagonized the effect of noradrenaline, producing a parallel shift to the right of the noradrenaline inhibition curves. From these data pA 2 (apparent affinity) values of 6.8 and 7.3 were calculated for PmP on presynaptic α 2-adrenoceptors located on noradrenergic and serotonergic nerve terminals, respectively.
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