Abstract
The serotonin precursor 5-hydroxytryptophan and the serotonin-like agent quipazine (2-(1-piperazinyl)quinoline), were found to antagonize tremorine-induced tremor in mice. Coadministration of quipazine and levodopa resulted in potentiation of the latter's antitremorine effect. 5-Hydroxytryptophan increased levodopa activity when administered before, but not simultaneously with the dopamine precursor. These data suggest that serotoninergic drugs may be useful in the treatment of Parkinson's disease and support the possibility of a relationship between serotonin deficiency and this disorder.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
