Abstract
We investigated the effects of propyl-β-carboline-3-carboxylate (β-CCP) on learning and memory tasks in a passive avoidance test in mice to clarify whether β-CCP is an agonist or antagonist at benzodiazepine (BZP) receptors. At doses up to 10 mg/kg i.V., β-CCP had no effect on mice in the passive avoidance test. Diazepam impaired passive avoidance behavior and methyl-β-carboline-3-carboxylate(β-CCM) enhanced it. β-CCP blocked these effects of diazepam and β-CCM in a dose-dependent manner similar to the effect of Ro15-1788. These effects of β-CCP, which are thought to be mediated by BZP receptors, indicate that β-CCP is an antagonist in the passive avoidance test.
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