Abstract

A. They certainly can. Anticholinergics, like many commonly prescribed drugs, may cause side effects interfering with the sexual response cycle. Atropine, scopolamine, and related belladonna alkaloids can cause erectile problems via their ganglionic-blocking properties. Antidepressants vary in the degree to which they have either anticholinergic or alpha-adrenergic blocking properties. Those antipsychotics that have anticholinergic properties also disrupt the smooth sequence of the sexual response, with erectile and/or ejaculatory difficulties. Some antihistamines antagonize acetylcholine activity and again can cause erectile problems. Any drug that can cause a dry mouth should raise a suspicion that the patient may also be experiencing sexual side effects. If so, an alternative medication can usually be substituted.

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