Abstract
Purpose: Osteoarthritis (OA), the most common joint disease for which no effective therapy currently exists, has a complex pathogeny with diverse interacting factors causing articular cartilage damage and alterations in other joint tissues. We previously described an association between polymorphisms in the acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) gene and OA. Recently, we discovered that ANP32A protects against OA by promoting expression of antioxidant enzyme ATM in cartilage, thereby reducing oxidative stress.
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