Abstract
Transient receptor potential channels (TRP), in particular, TRPCs and TRPMs are recognized as important determinants of myogenic vascular tone and vascular diameter. Physiological and pharmacological properties of an other TRP (vanilloid receptor-1, TRPV1) were studied. It was found that (1) TRPV1 is expressed in vascular smooth muscle cells; (2) stimulation of vascular TRPV1 results in a substantial constriction in the gracilis artery of the rat and mouse; (3) this effect is missing in TRPV1 knock out mice or in the presence of TRPV1 specific inhibitors; (4) constriction is mediated by TRPV1 dependent increase in smooth muscle intracellular Ca2+ concentrations; (5) pharmaceutical properties of vascular TRPV1 are different from the sensory neuron located TRPV1. Our data suggests that vascular TRPV1 may be a new pharmaceutical target in the regulation of tissue perfusion, and may also represent an undesirable target for antinociceptive TRPV1 antagonists being developed.
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