Abstract
Sorption of binary solvents water/dioxane and water/n-propanol in glassy poly(2-hydroxyethyl methacrylate) matrices and concomitant release of theophylline was investigated. The observed sorption profiles of the penetrant as well as the release profiles of theophylline have been explained on the basis of the effect of penetrant concentration on the diffusivity of the penetrant and of theophylline. The model parameters estimated from the release profiles agree well with the values for which an initial burst followed by release at constant rate is predicted.
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