Abstract

To gain insight into the mechanisms of ionophoric activity of usnic acid (UA), we examined the UA-induced generation of potentials on a planar bilayer lipid membrane (BLM) in the presence of concentration gradients of hydrogen and magnesium or calcium ions under open-circuit conditions. Remarkably, the BLM potential generated by UA at the proton concentration gradient of 1 pH unit was approximately twice the Nernst equilibrium level. With a concentration gradient of magnesium or calcium ions, the BLM potential generated by UA had the opposite sign. The observed anomalies in the membrane potentials were consistent with a theory developed by Markin and Sokolov (Bioelectrochem. Bioenerg. 1990) for the case of ionophore-mediated coupled fluxes of several ions across a membrane.

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