Abstract
THE clinical picture of varicella, like that of other infectious diseases, presents wide variation. Besides the known irregularities in rash distribution, anomalies of the prodromal period and of the exanthem have been described (Schamberg and Kolmer, 1928a; Ronaldson and Kelleher, 1938). In the present paper, the relevant features of five cases are presented and the apparent association of the anomaly with a previous skin condition is pointed out in three cases. All five cases were observed between 1954 and 1955 when no laboratory technique was available for identification of varicella virus or antibody. In three cases, fluid collected from vesicles was inoculated on the chick-embryo chorioallantois after treatment with a mixture of penicillin and streptomycin. Reinoculations of the original inocula and serial blind passages were made to eliminate the possibility of variola virus being the agent involved since this virus may sometimes fail to provoke typical lesions (MacCallum, I954). Besides, the failure to find chorioallantoic lesions supported the clinical diagnosis since varicella virus does not provoke lesions (Irons, Bohls, Cook and Murphy, I941; MacCallum, 1954). Biopsies of representative skin lesions were made in two cases and the histological findings were interpreted in the light of recent reviews of the pathology of viral pocks (Lever, 1949; McNair Scott, Blank, Coriell and Crouse, I950).
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