Abstract
Under normal conditions, the outer layers of the AF are innervated by sensory nerve endings from thedorsal root ganglion, whereas in patients with discogenic low back pain, sensory nerve endings and blood vessels are frequently observed in the inner layer of the AF and the nucleus pulposus (NP). Such nerve ingrowth and neovascularization is thought to be one of the major sources of discogenic low back pain and can occur as a consequence of the local production of angiogenic and neuronogenic factors in annular injury.
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