Annular Elastolytic Giant Cell Granuloma - A Rare Case with Systemic Involvement

Arun Achar,Joyeeta Chowdhury,Sangita Patra,Suchibrata Das

doi:10.3329/bjms.v15i3.29036

Abstract

Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous dermatosis characterized by loss of elastic fibers and elastophagocytosis by multinucleated giant cells. It is characterized by annular plaques that are similar to those observed in granuloma annulare but that specifically appear in sun-exposed skin and occurs more commonly in females than males. There have been reported cases of AEGCG associated with diabetes mellitus, systemic sarcoidosis, cutaneous amyloidosis, molluscum contagiosum, squamous cell carcinoma of the lung and cutaneous T-cell lymphoma. We report a case of AEGCG in both sun-exposed as well as covered areas of a middle aged lady with hepatic nodules and Barrets esophagus.Bangladesh Journal of Medical Science Vol.15(3) 2016 p.488-491

Highlights

The term annular elastolytic giant cell granuloma (AEGCG) was first proposed by Hanke et al[1] to include similar clinical cases that had been diagnosed as atypical necrobiosis lipoidica of the face and scalp, Miescher’s granuloma of the face[2], and actinic granuloma
The most common clinical presentation consists of annular plaques or patches often with elevated borders and central atrophy 4, Clinically, Annular elastolytic giant cell granuloma (AEGCG) presents as multiple, large, annular plaques with a raised, erythematous border and central atrophy
The lesions are mostly located on sun-exposed areas such as the face and neck, but they are seen on nonexposed skin rare reports of a papular variant of AEGCG exist 5, 6

Summary

Introduction

The term annular elastolytic giant cell granuloma (AEGCG) was first proposed by Hanke et al[1] to include similar clinical cases that had been diagnosed as atypical necrobiosis lipoidica of the face and scalp, Miescher’s granuloma of the face[2], and actinic granuloma. Introduction: The term annular elastolytic giant cell granuloma (AEGCG) was first proposed by Hanke et al[1] to include similar clinical cases that had been diagnosed as atypical necrobiosis lipoidica of the face and scalp, Miescher’s granuloma of the face[2], and actinic granuloma. Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease, which is characterized histologically by an absence of elastic fibres, due to elastophagocytosis by multinucleated giant cells in the dermis[3, 4] The majority of AEGCG cases have been identified in middle-aged, Caucasian women.

Results

Conclusion