Annual ryegrass toxicity in sheep is not prevented by administration of cyclodextrin via controlled release devices.

Abstract

Abstract The efficacy of cyclodextrin administered by one or two controlled release devices (CRDs) to treat experimental acute, subacute or chronic annual ryegrass (Lolium multiflorum) toxicity (ARGT) in sheep caused by corynetoxins (CT) produced by Rathayibacter toxicus was determined. R. toxicus-contaminated grass was harvested in Western Australia. It was shown that cyclodextrin administered using CRDs was not effective against ARGT. Glutamate dehydrogenase activity was similar between affected sheep with or without CRDs and required euthanasia.