Abstract
Brucellosis is a zoonotic disease caused mainly by the bacteria belonging to the genus Brucella, most common of them is Brucella abortus. Genome sequencing of Brucella was completed in 2005. While majority of the proteins were assigned function, a large number of the peptides remained un-annotated and were referred as 'hypothetical'. These hypothetical proteins may contain crucial information about the biology and pathogenesis of the B. abortus. Therefore, it is of interest to annotate one such hypothetical protein as a multiple antibiotic resistance regulator protein, MarR. The physiological parameters, localization and the structural features were predicted for this protein which corroborated as the winged-helix type DNA-binding domain superfamily of transcription factors.
Highlights
Brucellosis is a disease with many names such as malta fever, bang’s disease, Gibraltar fever, undulant fever and many more
Brucellosis is mostly found in domestic animals and it is caused by bacteria of Brucella species
Multiple Antibiotic Resistance Regulatory (MarR) proteins, first identified in Escherichia coli, are the members of winged helix-turn-helix family of transcription factors [17] and they negatively regulate the operon that encodes for the drug efflux pump system
Summary
Brucellosis is a disease with many names such as malta fever, bang’s disease, Gibraltar fever, undulant fever and many more. It has been a major cause of concern with almost 5,00,000 cases annually. Brucellosis is mostly found in domestic animals and it is caused by bacteria of Brucella species. Its transmission through untreated or contaminated milk is most common. Veterinary and abattoir accidents are another way of transmission. Brucella is a small gram-negative aerobic coccobacillus and a facultative intracellular parasite which includes B. abortus, B. melintensis, B. suis, B. neotomae, B. ovis, B. canis etc [1]
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