Abstract
The energy-generating membrane protein NADH dehydrogenase (NDH-2), a proposed antibacterial drug target (see “Inhibitors of type II NADH:menaquinone oxidoreductase represent a class of antitubercular drugs” Weinstein et al. 2005 [1]), was screened for modulators of activity in either detergent-solublised or lipid reconstituted (proteolipsome) form. Here we present an annotated list of compounds identified in a small-scale screen against NDH-2. The dataset contains information regarding the libraries screened, the identities of hit compounds and the physicochemical properties governing solubility and permeability. The implications of these data for future antibiotic discovery are discussed in our associated report, “Comparison of lipid and detergent enzyme environments for identifying inhibitors of membrane-bound energy-transducing proteins” [2].
Highlights
The energy-generating membrane protein NADH dehydrogenase (NDH-2), a proposed antibacterial drug target, was screened for modulators of activity in either detergent-solublised or lipid reconstituted form
We present an annotated list of compounds identified in a small-scale screen against NDH-2
The respiratory Type II NADH dehydrogenase (NDH-2) is an antimicrobial drug target and these annotated drug screening data provide information that may be used for further antimicrobial drug development
Summary
Cook a,b,n, Adam Heikal a,b,n a Department of Microbiology and Immunology, University of Otago, Dunedin 9054, New Zealand b Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Private Bag 92019, Auckland 1042, New Zealand article info. Article history: Received 20 November 2015 Received in revised form 8 December 2015 Accepted 11 December 2015 Available online 17 December 2015
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