Abstract
Chloramphenicol, an antibiotic used to treat bacterial infections, is also implicated in severalconditions, including aplastic anaemia that progresses to leukaemia. The modulatory potential ofleaf extract of Annona muricata on chloramphenicol-induced lymphoma (CIL) in female Wistarrats was investigated. Forty-eight adult female rats with an average weight of 186 g wererandomized into 6 groups of 8 rats each. Rats in Group 1 served as the positive control. Each ratin Groups 2-6 was orally administered with 250 mg/kg bodyweight chloramphenicol once dailyfor 28 days. The rats were given access to basal diet and water. After 28 days, blood-film analyseswere carried out from each of the groups. The presence of blast and lymphoproliferative cells inGroups 2-6 confirmed CIL. Groups 1 and 2 rats received distilled water, while Groups 3-6received 500, 1000, 1500, and 2000 mg/kg, respectively, of A. muricata for another 28 days. Theanimals were anesthetized, blood was collected from the retro-orbital venous plexus fordetermination of haematological indices; oxidative stress markers; lactate dehydrogenase,superoxide dismutase, catalase, glutathione, malondialdehyde, cardiac markers; Troponin-1,myoglobin, cancer indices; C-reactive protein, carcinoembryonic antigen, Alpha-fetoprotein.There was significant (p<0.05) amelioration of impaired haematological indices in the treatedgroups when compared to Group 2. Troponin-I and myoglobin were significantly (p<0.05)lowered in the treated groups when compared to Group 2. Oxidative stress markers and cancerindices were increased in Group 2, but significantly (p<0.05) ameliorated in Groups 3-6.Therefore, A. muricata has the potential to modulate adverse effects of CIL.
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