Annexin A3, a Calcium-Dependent Phospholipid-Binding Protein: Implication in Cancer.

Liu Yang,Song Qu,Xiaohui Yang,Kaiguo Li,Pingan Lu

doi:10.3389/fmolb.2021.716415

Liu Yang, Song Qu + Show 3 more

Open Access

https://doi.org/10.3389/fmolb.2021.716415

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Abstract

Annexin A3 (ANXA3), also known as lipocortin III and placental anticoagulant protein III, has been reported to be dysregulated in tumor tissues and cancer cell lines, and harbors pronounced diagnostic and prognostic value for certain malignancies, such as breast, prostate, colorectal, lung and liver cancer. Aberrant expression of ANXA3 promotes tumor cell proliferation, invasion, metastasis, angiogenesis, and therapy resistance to multiple chemotherapeutic drugs including platinum-based agents, fluoropyrimidines, cyclophosphamide, doxorubicin, and docetaxel. Genetic alterations on the ANXA3 gene have also been reported to be associated with the propensity to form certain inherited, familial tumors. These diverse functions of ANXA3 in tumors collectively indicate that ANXA3 may serve as an attractive target for novel anticancer therapies and a powerful diagnostic and prognostic biomarker for early tumor detection and population risk screening. In this review, we dissect the role of ANXA3 in cancer in detail.

Highlights

Annexin A3 (ANXA3), a water-soluble protein consisting of 323 amino acid residues, is encoded by the ANXA3 gene located on human chromosome 4q13–q22 (Mussunoor and Murray, 2008)
The high mortality rate of many cancers can be attributed to the evasion of detection of benign or preneoplastic tumors, the occurrence of intrinsic or acquired therapy resistance, and the suboptimal predictive power of the routinely used screening techniques and clinicopathological parameters
Emerging evidence has suggested that ANXA3 might be a promising biomarker candidate and an attractive therapeutic target that harbors the potential to address these obstacles

Summary

Introduction

Annexin A3 (ANXA3), a water-soluble protein consisting of 323 amino acid residues, is encoded by the ANXA3 gene located on human chromosome 4q13–q22 (Mussunoor and Murray, 2008).

Results

Conclusion