Abstract
To investigate the value of expression of annexin A2, microvessel density (MVD) and CD105 in pancreatic ductal adenocarcinoma (PDAC) tissues and adjacent normal tissues, immunohistochemical staining was used. The positive expression rate of Annexin A2 and the MVD in pancreatic ductal adenocarcinoma tissues was higher than that in in adjacent normal tissues (p<0.005). Expression of Annexin A2 and MVD correlated with histological grade (p<0.05). MVD of cancers in TNM stage IIb was higher than that in TNM stageI~IIa (p<0.026). Cancerous tissues with Annexin A2 staining grade 3+ had lower MVD than the tissues with the other Annexin A2 staining grade (p<0.05). Patients with high MVD had worse prognosis. However , our study did not confirm Annexin A2 was an independent risk factor for patients with PDAC. We confirmed MVD labeled by CD105 was an independent risk factor for patients with PDAC and had moderate predictive value of prognosis.
Highlights
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with an actuarial mortality rate is about 90% (Cheung, 2013), corresponding to the fourth leading cause of cancer death
The disorder of Annexin A2 expression is related to the tumorigenesis in a variety of tumor, The data shows Annexin A2 play an important role in the process of tumor invasion and metastasis, and could be used as predictor biomarker of cancer (Alonso-Alconada et al, 2014)
Annexin A2 Staining In pancreatic ductal adenocarcinoma and it’s association with Clinicopathological Characteristics
Summary
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with an actuarial mortality rate is about 90% (Cheung, 2013), corresponding to the fourth leading cause of cancer death. To investigate the value of expression of annexin A2, microvessel density (MVD) and CD105 in pancreatic ductal adenocarcinoma (PDAC) tissues and adjacent normal tissues, immunohistochemical staining was used.
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