Análisis de espectros de resonancia magnética

Abstract

ObjectiveTo study the performance in the use of metabolite ratios and the comparison of a contralateral volume of interest in order to determine which of these two techniques is most suitable for obtaining a ratio of the metabolite behaviour of a magnetic resonance spectrum. MethodsThe parietal lobe, the temporal lobe, and basal ganglions were analysed in the 10 healthy volunteers included in the study. ResultsThe direct quantification of the spectra showed a wide coefficient of variation within the analyses performed, which justified using techniques with endogenous references. The study of a contralateral volume showed to be a technique with a high dispersion and laterality index. The use of creatinine (Cr) as a control metabolite had a lower coefficient of variation than the first technique evaluated. The results obtained (basal ganglions: N-acetyl-aspartate/Cr: 3±6; choline/Cr: 2±4. Temporal lobe: N-acetyl-aspartate/Cr: 5±5; choline/Cr: 8±12. Parietal Lobe: N-acetyl-aspartate/Cr: 2.0±0.6; choline/Cr: 0.9±0.5) showed similar values to those obtained in the literature, with considerable anatomical region variations. ConclusionsThe technique that measures the ratio of the metabolites with Cr is the most suitable for use in the Instituto Nacional de Cancerología (National Oncology Institute), due to having a lower dispersion and producing results near those repo rted in the literature in the different anatomical regions studied.