Abstract
The objective of this study was to evaluate serum hematological and biochemical changes in obese young dogs clinically healthy. Twenty-six animals were selected, which were separated into two groups: thirteen with normal weight and thirteen with obesity. Exclusion criteria were used for the selection of groups, age between one and eight years, physical evaluation, blood count, and a questionnaire to investigate pre-existing pathologies (diabetes mellitus, hypothyroidism, hyperadrenocorticism, hepatic and/or renal insufficiency, congenital or acquired heart disease, locomotor problems, inflammatory and/or infectious diseases or physiological conditions such as pregnancy or lactation). 5-mL blood samples were collected from each patient by puncture of the cephalic vein in the morning after a feeding restriction of 10 hours. Hematocrit, total erythrocyte count, hemoglobin concentration, total leukocyte count, leukocyte differential count and serum albumin, total protein, globulins, ALT, ALP, HDL cholesterol, total cholesterol, triglycerides, creatinine, urea, glucose, and insulin were assessed. No statistically significant differences were found between the groups in the hematological assessments. Among the biochemical tests, there were significant differences in total cholesterol, HDL cholesterol, and glucose (p ≤ 0.05).
Highlights
Obesity is considered a very common nutritional disorder in dogs and is a major risk factor for several diseases (GERMAN, 2010), which can lead to comorbidities such as locomotor system disorders, impairment of the immune response, cardiorespiratory, endocrine (LAFLAMME, 2006), dermatological, reproductive and dyslipidemic diseases; and longevity interference (KEALY et al, 2002)
It was observed that the animals in the obese group were young adults, which is worrying because there is a tendency for weight gain to increase with age (DIEZ, 2006)
Obesity is related to inflammatory diseases with the production of pro-inflammatory cytokines, such as interleukin-6 and alpha tumor necrosis factor, which cause persistent, low-grade inflammation; there is usually no evident change in the leucogram, but there is a greater production of globulins (ECKERSALL, 2008)
Summary
Obesity is considered a very common nutritional disorder in dogs and is a major risk factor for several diseases (GERMAN, 2010), which can lead to comorbidities such as locomotor system disorders, impairment of the immune response, cardiorespiratory, endocrine (LAFLAMME, 2006), dermatological, reproductive and dyslipidemic diseases; and longevity interference (KEALY et al, 2002). Obesity is becoming a medical concern as the prevalence is increasing in dogs and in their owners (GERMAN, 2010). Obesity can trigger several metabolic disorders because adipose tissue is an endocrine organ that participates in the metabolism of lipids, carbohydrates, and energy regulation. The objective of this study was to determine differences in hematological and serum biochemical indices in normalweight and obese dogs The association between obesity and metabolic syndrome (MS) in veterinary medicine is still widely discussed and controversial (CLARK; HOENIG, 2016).
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