Análise da variabilidade da frequência cardíaca em indivíduos saudáveis, doentes com insuficiência cardíaca e doentes transplantados

Abstract

This study aimed to find parameters to characterize heart rate variability (HRV) and discriminate healthy subjects and patients with heart diseases. The parameters used for discrimination characterize the different components of HRV memory (short and long) and are extracted from HRV recordings using parametric as well as non parametric methods. Thus, the parameters are: spectral components at low frequencies (LH) and high frequencies (HF) which are associated with the short memory of HRV and the long memory parameter (d) obtained from autoregressive fractionally integrated moving average (ARFIMA) models. In the non parametric context, short memory (α1) and long memory (α2) parameters are obtained from detrended fluctuation analysis (DFA). The sample used in this study contains 24-hour Holter HRV recordings of 30 subjects: 10 healthy individuals, 10 patients suffering from congestive heart failure and 10 heart transplanted patients from the Noltisalis database. It was found that short memory parameters present higher values for the healthy individuals whereas long memory parameters present higher values for the diseased individuals. Moreover, there is evidence that ARFIMA modeling allows the discrimination between the 3 groups under study, being advantageous over DFA.