Abstract
This review focuses on the methods of study that investigated the anxiolytic effects of new drugs with animal models. In a research setting, researchers investigate inquiry and recognition behavior changes of animals with anxiety in response to drug therapy. This forms the basis of a research. Although, “anxious” behaviors of rats do not exactly match the actual human behavior, they are still used as a model of human behavior. Several different stressor agents have been used including electric shocks, tilting the cage, olfactory bulbectomy, elevation of the setup, changing the lighting situation, under water trauma or exposure to predator materials. In these studies, generally the reaction to the stress is tested by observing the changes in the “anxious” behavior, cognitive impairment, fear and decreased social interaction. Frequently used models are; open field test, forced swimming test, social isolation, conflict tests, repeated stress test, tail suspension test, elevated maze tests, single prolonged test and chronical mild stress predator scane test. We explain various rat models and their properties and show how they are used to create anxiety with different stressor agents. Ease and repeatability of these models suggest that they are effective for studying drugs for the prevention and treatment of anxiety
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