Abstract
For its medicinal potential, especially in cancer therapy, eco-friendly gold nanoparticles (GNPs) have gained a lot of interest. This investigation used Litchi chinensis leaf extract (LLE) as a reducing agent for the one-step synthesis of regulated-size GNPs. Fourier transform infrared (FTIR) spectrum shows that the bio-molecules act as capping and reducing agents. The formation of GNPs has been confirmed using UV-vis absorption spectra. Effect of various synthesized parameters, i.e., reaction time (5–120 minutes), temperature (25–100°C), solvent quantity (5–45 μL), metal ion concentration (0.25–2 mM) and pH (2–10) has been studied. The size, distribution, and morphology (anisotropic) have been studied using field emission scanning electron microscopy (FESEM) and dynamic light scattering (DLS) techniques in the range of 10 to 70 nm. X-Ray diffraction (XRD) reveals that the particles were crystalline and had face-centered cubic (FCC) structure, and transmission electron microscopy (TEM) images revealed anisotropic morphology (spherical, hexagonal, and triangular). In-vitro studies of GNPs on breast cancer cell lines show cytotoxicity with cellular structural alterations and caused DNA damage without the micronuclei formation.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
