Abstract
In the course of an examination of school children a few years ago, I encountered a child with hereditary absence of the iris. Tracing her family and relatives, I was able to find nine cases of aniridia and obtain a good family history of fifteen cases in five generations. Some of the children are in school but are seriously handicapped. On a casual inspection of the eye, there seems to be a total absence of the iris, although it is probable that on close examination tags or remnants of this structure remain, as is reported in the majority of cases examined. In this anomaly the influence of heredity is most strikingly seen. The character behaves as a mendelian dominant. The laws of heredity, so well worked out in plants and lower animals, encounter many obstacles in their application to conditions in man. This is due principally to the difficulty in
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