Abstract
Vaccination is one of the main methods for the specific prevention of infectious diseases. The disadvantage of vaccination is the use of pathogens (live or attenuated viruses and bacteria) that can lead to the development of a disease. Recombinant technologies are capable of producing specific DNA or protein molecules that possess antigenic properties and do not cause disease. However, individual antigen molecules are low-immunogenic, and therefore, require conjugation with a compound possessing stronger immunogenic properties. In this study, we examined the immunogenic properties of the new anionic copolymer consisting of glycidyl methacrylate, butyl acrylate, triethylene glycol dimethacrylate, and acrylic acid, in mice. The experimental polymer induced a stronger immunogenic response than aluminum hydroxide. The histological studies have established that immunization both with aluminum hydroxide and the polymer studied does not cause damage to the liver, kidneys, or the spleen. No negative side effects were observed. It has been concluded that the new synthetic anionic polyelectrolyte hydrogel (PHG) has a potential as an adjuvant for vaccine development.
Highlights
Vaccination is the best way to protect organisms from infectious diseases
From the original Latin word meaning “helping” or “aiding”, is an agent that amplifies the effect of a vaccine
The characteristics of synthesized cured hydrogels are presented in the Table 1
Summary
Vaccination is the best way to protect organisms from infectious diseases. Vaccines improved the quality of life, work productivity, and social equity of a population by averting untold numbers of disabling post-infection disease sequelae, most notably blindness, deafness, and neurological disorders [1,2,3]. Vaccines can have various side effects such as allergy, muscle pain, headache, swelling, shivering, and mild fever. Live attenuated viral or bacterial vaccines can cause infection or morbidity. Safe individual antigen molecules such as specific DNA sequences or proteins have low immunogenicity and, require conjugation with a compound possessing stronger immunogenic properties. From the original Latin word meaning “helping” or “aiding”, is an agent that amplifies the effect of a vaccine. Le Moignic and Pinoy described the first adjuvant—an emulsion of mineral oil and lanolin—in 1916 [4]
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