Anionic Cascade Routes to Sulfur and Nitrogen Heterocycles Originating from Thio‐ and Aminophosphate Precursors

Abstract

This micro‐review attempts to comprehensively cover reported reactions employing thio‐ and aminophosphate precursors for forming sulfur and nitrogen heterocycles. All such reactions are triggered by initial formation of an alkoxide, most commonly by attack of a carbon or heteroatom nucleophile onto a carbonyl group. The alkoxide intermediate facilitates an intramolecular transfer of the phosphate group to form a thiolate or nitrogen atom anion, which then terminate the anionic cascade via an intramolecular O‐phosphate displacement reaction to form the heterocyclic products.