Abstract
Abstract Objectives The potent antioxidant activity of Eriobotrya japonica seed extract (ESE) and its usefulness in the prevention and treatment of various disorders has been reported previously. Its antioxidant activity associated with β-sitosterol and polyphenols contained in the extract was also validated. In this study, anti-allergic activity of Eriobotrya japonica seed extract was investigated. Methods The inhibition of histamine release-mediated type 1 allergy by Eriobotrya japonica seed extract was used as an index. Key findings The administration of this extract inhibited histamine release from rat mast cells, suggesting its usefulness in allergic disease treatment. In an experiment using a guineapig allergic rhinitis model, this extract reduced the frequency of sneezing and nose-scratching. Conclusions These results suggest that Eriobotrya japonica seed extract may contribute to the relief of allergic disease-related symptoms.
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