Abstract
Retinal degenerations (RDs) are a vast and heterogeneous group of inherited degenerative diseases (dystrophies) of the retina that lead to progressive visual loss. The study of RDs involves animal models of various forms: from those naturally occurring to those genetically engineered, from insects to mammals. In particular, the mouse models from the Jackson Laboratory, with their well characterized phenotype, locus of mutation and corresponding human genetic homolog, have been extensively used in RD research.
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