Abstract
Obsessive-compulsive disorder (OCD) is characterized by obsessions (intrusive thoughts, images etc.) and compulsions (repetitive, stereotyped and perseverant acts). Animal models of OCD are specifically devoted to simulating compulsive features of the disorder. In OCD, compulsive behaviors are recognized as repetitive and maladaptive and symptoms relief can be experienced due to treatment with selective serotonin reuptake inhibitors. Many animal models of OCD are provided with some degree of validity. Genetically based differences in behavior in animal models of OCD are of great value, given that human OCD is reported to involve genetic factors. Some animal models of OCD were already used in studies for the evaluation of strain differences. These works were explored in the present review.
Highlights
Obsessive-compulsive disorder (OCD) is characterized by obsessions and compulsions
A selective breeding program for phenotypes of increased or decreased amounts of a compulsive behavior could be a heuristic tool for studying OCD
Just a few were used for evaluating strain differences
Summary
Obsessive-compulsive disorder (OCD) is characterized by obsessions (intrusive thoughts, images etc.) and compulsions (repetitive, stereotyped and perseverant acts). When confined to captivity, different species frequently show stereotypy (e.g. vervet monkeys) In both examples, SSRI treatment is able to decrease the compulsive behavior [9] [10]. Since genetic factors seem to be involved in OCD, studying these factors in animal models is important both for the validation of the model and for improving knowledge about the disorder. A selective breeding program for phenotypes of increased or decreased amounts of a compulsive behavior could be a heuristic tool for studying OCD. Such kind of program was successfully achieved in respect to nest building behavior in mice [11]. The available information about these differences is explored
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