Abstract
Infantile spasms(IS), an age-dependent epileptic encephalopathy seen in infancy, is characterized by unique electro-clinical features and pharmacological reactions.Most conventional antiepileptic drugs are ineffective for IS.Hormonal treatment(including adrenocorticotropic hormone ACTH, and oral steroids)and vigabatrin(VGB)now widely used as first-line treatments for IS, have certain effects on IS, but the effect of these two options on long-term outcomes has not been established.The etiology of IS is variable.It is unclear that how a wide variety of conditions result a common phenotype.Ideal animal models can help to understand pathogenesis of disease and explore new therapies to improve the ultimate outcome.This review summarizes the research status of animal models of IS. Key words: Infantile spasm; Animal model; Pathogenesis; New drug therapy
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