Abstract
Animal models of dry eye: a critical assessment of opportunities and limitations.
Highlights
It has become clear that the immunopathogenesis of dry eye is complex and multifactorial
Sjogren’s syndrome, which is the classic form of exocrine deficiency associated with keratoconjunctivitis sicca (KCS), is characterized by a chronic inflammatory infiltration of the lacrimal and salivary glands
The observation that lacrimal gland acinar cells may express class II major histocompatibility complex (MHC) molecules, cathepsins B and D, and ribonucleoprotein particle La/SSB proteins has provided some support for the thesis that these cells may be involved in aberrant presentation of autoantigens, thereby potentially capable of priming autoreactive T cells.[4]
Summary
“Animal Models of Dry Eye: A Critical Assessment of Opportunities and Limitations.”. Investigative Opthalmology & Visual Science 45 (6) (June 1): 1641.
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