Animal models of cerebral venous and sinus thrombosis

Abstract

Cerebral venous and sinus Thrombosis (CVST) is a rare ischemic cerebrovascular disease, the lesions of 60% patients are involved in multiple venous sinus, of which the superior sagittal sinus thrombosis is most common. The pathogenesis and pathophysiology of CVST has not yet been fully elucidated, and the establishment of stable and ideal animal models can provide a basis for the study of its development, prognosis and efficacy assessment. This article summarizes the characteristics and advantages of several available CVST models, but each method has its own limitations. Therefore, the establishment of a more ideal animal model will help to fully understand the pathogenesis and pathological process of CVST. Key words: Sinus Thrombosis, Intracranial; Venous Thrombosis; Disease Models, Animal