Abstract
Animal Models of Alzheimer's Disease
Highlights
(ii) Mechanistic studies of Alzheimer’s disease (AD)-related pathology in animal models including but not limited to APP/Aβ and/ or tau hyper-phosphorylation
These models have become promising tools to decipher the mechanistic importance of tau phosphorylation and Aβ deposits, as well the relationship between each other, other pathological AD-related events, and cognitive loss
While seemingly obvious, it is important to remember that the validity of an animal model of disease is tightly linked to the ability of the animal to mimic the signs of the disease— which goes beyond the pathology and needs to include cognitive decline and neuronal loss
Summary
(ii) Mechanistic studies of AD-related pathology in animal models including but not limited to APP/Aβ and/ or tau hyper-phosphorylation (i.e., oxidative stress, mitochondrial, inflammatory, cell cycle changes etc.). These models have become promising tools to decipher the mechanistic importance of tau phosphorylation and Aβ deposits, as well the relationship between each other, other pathological AD-related events, and cognitive loss.
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