Abstract
AbstractThe high incidence and mortality of gastrointestinal (GI) cancer always attracted a great deal of attention from academia and industry. Efforts have been made to clarify the pathogenesis of GI cancer and identify therapeutic targets, which led to profound progress in the establishment and application of animal models. Currently, the study of cancer microbiome marks one of the most important trends in this field, putting forward demands that animal models be more elaborate. In this chapter, we have profiled representative animal models used in major types of GI cancer to support the study of corresponding microbiome, along with the findings obtained based on them. Looking to the future, animal models need to be further upgraded to conform to academic and industrial demands for establishing causality and developing microbiome therapeutics.KeywordsAnimal modelsGI cancerMicrobiomeGerm-freeCausal relationship
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