Animal Models for Pre-Clinical Antiepileptic Drug Research

Abstract

Animal models are essential in preclinical anti epileptic drug research. These models serve different purposes in epilepsy research and in drug discovery and development of anti epileptic drugs to evaluate efficacy, to determine mechanism of action, used to determine preclinical efficacy of new drugs during chronic administration, to study the mechanism of drug resistance and also used to study whether eplileptogenesis alters the adverse effect potential of a given drug. A large number of in vivo animals models are used, some important which can be adapted and acclimatized to institutional laboratory settings discussed.