Animal Model of Neurodegeneration and Stress Cause by Aluminum Toxicity

Abstract

Electrocortical group neuron activity describe changes in neurotransmision cause by different factors. Such changes could by qualitative described by spectral analysis of electrocortical activity as a variation of relative spectral power in different frequency ranges. We used fractal dimension to compare treated animals with control to quantitativily describe degree of pathophysiological state. The aim of this study was to qualitativily and quantitatively evaluate effect of the stress and the neurodegeneration in animal model of chronic intoxication by aluminum. This animal model is comparible with Alzheimer’s disease and Parkinson disease. By spectral and fractal analysis we described changes in electrocortical activity of aluminum intoxication compare to physiological control. We used adult animals, during 6 weeks intraperitonealy treated with aluminum. Stress was cause by experimental treatmant and immobilization. Neurodegeneration was observed histologicaly. Results shows that decrease in delta range of spectral power and fractal dimension might be used for evaluation of pathophysiological state of stress and neurodegeneration.