Abstract
Background and purpose: Of the animal models used for the study of bronchopulmonary dysplasia (BPD), the rodent has advantages over other species: At birth the rats have a stage of lung development equivalent to that of premature humans; in addition, their reproductive cycles and gestation period are of short duration (O'Reilly, 2015). Most animal models use hyperoxia cycles, but introducing intermittent episodes of hypoxemia (inspiratory oxygen fraction of 8% to 10%) mimics more closely the clinical scenario to which preterm infants are exposed, and the deleterious effect of …
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