Abstract

Cloning is powerful tool for production of genetically identical copies of desired donor animal but its success is still questionable. Due to number of factors, many scientist and common people are against cloning. Up to now it’s consider as inefficient technique due to high failure of cloned animal growth from gestation to adulthood. Mostly losses in cloned animals are due to placental abnormalities, cardiovascular and respiratory problems. These anomalies are most likely due to incorrect epigenetic reprogramming of the donor genome, leading to inappropriate patterns of gene expression during the development of clone. “Large offspring syndrome” is an example of phenotypic anomalies in cloned animals. Including this animals’ welfare, health and the significant consequence on food safety are reason behind its insufficiency. That’s why still more work need to understand exact cause of failure during pre- and postnatal development of cloned. This article generally focused the problems, due to which cloning is considered as an inefficient technique.

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