Abstract
One pot synthesis of quinazolin-1-one derivatives has been achieved from 2aminobenzothaizoles, 1,3-cyclohexanedione and aromatic aldehydes in presence of anhydrous zinc chloride catalyst. This methodology provides several advantages simple & mild reaction conditions and excellent yield.
Highlights
In recent year heterocyclic compounds analogues of benzothaizoles and derivatives have attracted strong interest due to their useful biological and pharmacological properties.1-5 The chemistry of quinazolinones is interested because of its biological significance
The common methods used for the preparation of such compounds are using tetramethylguanidinium trifluoroacetate ionic liquid,13 PTSA,14 dimethyl formamide (DMF)-K2CO3,15 THF,16 microwave irradiation
There is scope for further work on this reaction towards mild reaction condition, simple work up, and better yield. This has been achieved by using anhydrous zinc chloride as a catalyst to afford the corresponding quinazolin-1one in excellent yields
Summary
In recent year heterocyclic compounds analogues of benzothaizoles and derivatives have attracted strong interest due to their useful biological and pharmacological properties.1-5 The chemistry of quinazolinones is interested because of its biological significance. The common methods used for the preparation of such compounds are using tetramethylguanidinium trifluoroacetate ionic liquid,13 PTSA,14 DMF-K2CO3,15 THF,16 microwave irradiation.17 These methods have several limitations such as, pro-long reaction time, strong acidic condition and low yield. This has been achieved by using anhydrous zinc chloride as a catalyst to afford the corresponding quinazolin-1one in excellent yields. We wish to report an efficient and mild protocol for the synthesis 2,3,4,12-tetrahydro-benzo-[4,5]-thiazolo-[2,3b]-quinazolin-1-one using zinc chloride as catalyst.
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