Abstract
Long-term controversy regarding the role of angiopoietin-like protein 8 (ANGPTL8) in beta-cell proliferation and diabetes progression made it a research spotlight. Recently, the controversy was resolved. Although ANGPTL8 could not control beta-cell expansion and islet function, ANGPTL8 was still considered as a novel but atypical member in the ANGPTL family because of its unique structure and crucial effects on lipid metabolism. Besides, ANGPTL8 also participated in some other disorders such as non-alcoholic fatty liver disease and renal dysfunction. Understanding the features of ANGPTL8 may offer new diagnostic and therapeutic approaches to metabolic-related diseases. Therefore, we reviewed most recent findings about ANGPTL8 and aimed to provide an integrated picture of ANGPTL8.
Highlights
Angiopoietin-like proteins (ANGPTLs) are a group of secreted glycoproteins composed of eight members (ANGPTL1–8) [1]
Zhang et al proposed a potential mechanism to demonstrate the effects of angiopoietin-like protein 8 (ANGPTL8) on triglyceride metabolism in different nutritional states [25, 26]
Adipose triglyceride lipase (ATGL), a crucial enzyme involved in triglyceride hydrolysis in adipocytes, was downregulated and lipid was accumulated in adipose tissue [17]
Summary
Reviewed by: Sana Siddiqui, University of California, San Francisco, United States. ANGPTL8: An Important Regulator in Metabolic Disorders. Long-term controversy regarding the role of angiopoietin-like protein 8 (ANGPTL8) in beta-cell proliferation and diabetes progression made it a research spotlight. ANGPTL8 could not control beta-cell expansion and islet function, ANGPTL8 was still considered as a novel but atypical member in the ANGPTL family because of its unique structure and crucial effects on lipid metabolism. ANGPTL8 participated in some other disorders such as non-alcoholic fatty liver disease and renal dysfunction. Understanding the features of ANGPTL8 may offer new diagnostic and therapeutic approaches to metabolic-related diseases. We reviewed most recent findings about ANGPTL8 and aimed to provide an integrated picture of ANGPTL8
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