Abstract
A 67 year old female presented with generalized weakness, falls and recurrent high grade fevers for 5 - 6 weeks. Physical findings included high grade temperature, lower extremity weakness and diminished reflexes. An extensive work-up for fever of unknown origin (FUO), including PET-FDG scan, did not yield any occult infectious or neoplastic process. Ultimately a temporal artery biopsy was planned to rule out temporal arteritis. The histopathology of temporal artery was normal while the vein showed lymphoid proliferation consistent with Angiotropic large cell lymphoma (ALCL).
Highlights
Angiotropic large cell lymphoma (ALCL) is a rare malignancy with polymorphic clinical presentation and a high mortality rate if untreated
Some cases of angiotropic lymphoma have been reported in the past few years with recent case reports demonstrating the utility of PET-FDG imaging as a diagnostic tool for ALCL presenting as fever of unknown origin (FUO) [1,2,3,4]
Angiotropic Lymphoma is known as intravascular lymphomatosis, malignant angioendotheliomatosis or angioendotheliomatosis proliferans
Summary
Angiotropic large cell lymphoma (ALCL) is a rare malignancy with polymorphic clinical presentation and a high mortality rate if untreated. Some cases of angiotropic lymphoma have been reported in the past few years with recent case reports demonstrating the utility of PET-FDG imaging as a diagnostic tool for ALCL presenting as fever of unknown origin (FUO) [1,2,3,4].
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