Angiotensinogen gene polymorphism is associated with insulin resistance in nondiabetic men with or without coronary heart disease

Abstract

Background Variants of the angiotensinogen gene may increase the risk of having arterial hypertension and coronary heart disease (CHD), but their effect on insulin resistance remains unknown. Methods We determined M235 and T174 allele status and fasting plasma glucose, insulin, and lipids values in nondiabetic men with CHD documented on angiography ( n = 102) and in a control group ( n = 145). Plasma glucose and insulin responses to 75 gm oral glucose tolerant test and insulin resistance as measured by an insulin suppression test were also carried out in 46 (45%) patients with CHD and in 73 (50%) members of a control group. Results We found no association between M235T status and blood pressure, fasting plasma glucose, insulin, most of the lipids values, and insulin resistance in patients with CHD and normal subjects. Nevertheless, compared with individuals with homozygotes T174, subjects with heterozygotes T174M were associated with greater glucose and insulin response to the oral glucose tolerance test and insulin resistance indicated by higher steady state plasma glucose concentrations in patients with CHD (14.7 ± 0.9 vs 11.3 ± 0.7 mmol/L, p < 0.04). Similar findings were found in the control group, with higher steady-state plasma glucose values in individuals with heterozygotes T174M than in those with homozygotes T174 (10.1 ± 1.4 vs 7.7 ± 0.4 mmol/L, p < 0.05). Conclusion We suggest that the angiotensinogen T174M allele might be associated with insulin resistance in nondiabetic men with and without CHD. (Am Heart J 1998;136:125-31.)