Abstract
AbstractIn contrast to the current believe that angiotensin II (Ang II) only interacts with the sympathetic nervous system (SNS) as a circulating hormone, we document here the existence of an endogenous renin-angiotensin system (RAS) in the sympathetic coeliac ganglion and the angiotensinergic innervation with mesenteric resistant blood vessels. Our findings indicate that Ang II is synthesized inside the neurons of sympathetic coeliac ganglion and may act as an endogenous neurotransmitter locally on the mesenteric resistant blood vessels.
Highlights
In order to demonstrate the synthesis of angiotensin II (Ang II) in the coeliac ganglion, we investigated the presence of key components of the renin-angiotensin system (RAS)
Our study focused on the detection of different key components of RAS in sympathetic ganglions under normal physiological conditions
Thereby, we discovered the presence of an endogenous RAS in the normotensive rat sympathetic coeliac ganglion
Summary
In order to demonstrate the synthesis of Ang II in the coeliac ganglion, we investigated the presence of key components of the RAS. The presence of RAS components in circulation and at tissue level has been reported 1, but the question of endogenous synthesis of Ang II in the SNS has not been addressed so far. Our study focused on the detection of different key components of RAS in sympathetic ganglions under normal physiological conditions.
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