Abstract
BackgroundAbiraterone acetate (ABI) therapy improves overall survival in metastatic prostate cancer (PC) patients; however, this effect may be diminished by concurrent comorbidities. We aimed to evaluate the influence of pre-existing chronic diseases and concomitant medications on the course of ABI treatment among post-chemotherapy patients with metastatic castration-resistant prostate cancer patients (mCRPC).MethodsFrom the Polish National Health Fund database, we identified 93 post-chemotherapy, mCRPC patients, who were qualified for ABI treatment in our oncology center between 2014 and 2018. Survival curves and Cox proportional hazard models (univariate and multivariate) were used to determine the predictors for longer time to treatment failure (TTF) of ABI therapy.ResultsMedian TTF was 9,8 months (IQR: 0,6–56,5) Factors associated with longer TTF were: well controlled hypertension (HR, 0.59; 95% CI. 0.38–0.90; p = 0.02), stable coronary artery disease (HR, 0.56; 95% CI, 0.33–0.95; p=0.03), the use of angiotensin system inhibitor (ASi) (HR, 0.61; 95% CI 0.4–0.94; p = 0,02). Patients who were receiving ASi had median TTF of 12.2 months versus 5.8 months in men who did not receive ASi before ABI initiation. At the start of ABI therapy, the aforementioned groups did not differ in terms of well-known prognostic factors: Gleason score, PSA level, or the number of patients with visceral metastases. In a multivariate analysis, the use of ASi remained statistically significant, even after adjustment for well-known oncological factors (HR, 0.57; 95% CI, 0.34–0.98; p = 0.04).ConclusionsThe use of ASi may enhance and prolong ABI therapy in post-docetaxel mCRPC patients and may potentially be considered a new, non-oncological, predictive factor for longer TTF. This association requires a prospective validation.
Highlights
Prostate cancer (PC) is the most common cancer site diagnosed in men in Europe and USA [1, 2]
In our study we evaluated the influence of comorbidities and concomitant medications on the course of ABI treatment among men with metastatic castration resistant prostate cancer
The study provides the analysis of data from the Polish National Health Fund Drug Program database and the European Health Centre Otwock hospital’s records of metastatic castration-resistant prostate cancer patients (mCRPC) patients receiving ABI with prednisone who progressed after chemotherapy with docetaxel, and who were qualified for this treatment in our oncology center in the period between 2014 and 2018
Summary
Prostate cancer (PC) is the most common cancer site diagnosed in men in Europe and USA [1, 2]. Over the last decade the therapy of metastatic disease has been rapidly evolving and numerous new agents which improve overall survival have been developed. One of such important change was the approval of abiraterone acetate (ABI). It is the second-generation antiandrogen which blocks the synthesis of androgens via inhibition of CYP17A enzyme and impedes prostate cancer progression [3]. Abiraterone acetate (ABI) therapy improves overall survival in metastatic prostate cancer (PC) patients; this effect may be diminished by concurrent comorbidities. We aimed to evaluate the influence of pre-existing chronic diseases and concomitant medications on the course of ABI treatment among post-chemotherapy patients with metastatic castration-resistant prostate cancer patients (mCRPC)
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