Abstract
Geoffrey A. Donnan MD, FRACP Stephen M. Davis MD, FRACP Section Editors: Each year, stroke is responsible for 5.5 million deaths worldwide and the loss of >49 million disability-adjusted life-years. Interventions that effectively and efficiently prevent stroke therefore exert major economic, societal, and personal impact. An important modifiable risk factor for stroke is blood pressure, abnormal levels of which account for 54% of the worldwide burden of cerebrovascular disease.1 Unequivocal evidence supports blood pressure-lowering for preventing stroke both in primary and secondary prevention settings. Although most systematic reviews, including the series of analyses produced by the Blood Pressure Lowering Treatment Trialists’ Collaboration, suggest that all major classes of …
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