Abstract
The adrenal cortex plays a key role in the regulation of metabolism, salt and water homeostasis and sex differentiation by synthesizing glucocorticoid, mineralocorticoid and androgen hormones. Evidence exists that angiotensin II regulates adrenocortical function and it has been contended that angiotensin peptides of the non-canonical branch of the renin angiotensin system (RAS) might also modulate steroidogenesis in adrenals. Thus, the aim of this review is to examine the role of the RAS, and particularly of the angiotensin peptides and their receptors, in the regulation of adrenocortical hormones with particular focus on aldosterone production.
Highlights
The adrenal cortex plays a key role in the regulation of metabolism, salt and water homeostasis and sex differentiation by synthesizing glucocorticoid, mineralocorticoid and androgen hormones
Evidence exists that angiotensin II regulates adrenocortical function and it has been contended that angiotensin peptides of the non-canonical branch of the renin angiotensin system (RAS) might modulate steroidogenesis in adrenals
In a systematic search for the different receptor mRNAs, we recently found that all the angiotensin receptors, including the angiotensin type 2 receptor (AT2R), the Mas receptor RAS (MasR), and the alamandine receptor (MrgD) are expressed, albeit at a much lower level than the angiotensin type 1 receptor (AT1R) in the human adrenal cortex (Figure 1)
Summary
Gian Paolo Rossi* , Livia Lenzini , Brasilina Caroccia , Giacomo Rossitto , Teresa Maria Seccia.
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