Abstract
Angiotensin II receptor number was higher in superior cervical ganglia of 2-week-old when compared to 8-week-old rats. In both young and adult rats, specific binding of [ 125I][Sar 1]angiotensin II was displaced competitively by the AT 1-receptor antagonist DuP 753 but not by the AT 2-receptor competitor PD 123177. In ganglia from adult rats. DuP 753 competed with an IC 50 of 113 nM. The stable guanine nucleotide GTPγS inhibited binding of [ 125I][Sar 1]angiotensin II in young and adult rats by approximately 50% with IC 50 values of 105 and 120 nM, respectively, suggesting that the angiotensin receptor is G-protein linked. Angiotensin II at a dose of 1 μM stimulated inositol phosphate formation 58% over control values in superior cervical ganglia from 8-week-old rats. This effect was totally blocked by 10 μM DuP 753 but not by 10 μM PD 123177. Our findings demonstrate that rat superior cervical ganglia contain AT 1-type angiotensin receptors that are probably G-protein linked, and their stimulation results in increased inositol phospholipid metabolism.
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