Abstract
Patients with distributive shock still have a high mortality rate and remain an important issue for intensivists. Management of catecholamine-resistant shock in these patients poses a challenging problem. Despite significant advances in the knowledge of its pathophysiology, all innovative therapeutic approaches and interventions have failed to improve outcome. In the previous issue of Critical Care, Chawla and colleagues explored the impact of angiotensin II administration in patients with persistent hypotension despite adapted hemodynamic resuscitation. The authors demonstrate that, in case of distributive shock, angiotensin II is an effective vasopressor therapy. Its impact on outcome and adverse effects still needs to be further explored.
Highlights
Patients with distributive shock still have a high mortality rate and remain an important issue for intensivists
Distributive shock is mainly represented by septic shock [2]
The present study of Chawla and colleagues was designed to determine the appropriate dose of angiotensin II in the setting of distributive shock with high cardiac flow
Summary
Patients with distributive shock still have a high mortality rate and remain an important issue for intensivists. * Correspondence: b.levy@chu-nancy.fr 1CHU Nancy, Service de Réanimation Médicale Brabois, Pole Cardiovasculaire et Réanimation Médicale, Hôpital Brabois, 54511 Vandoeuvre les, Nancy, France 2INSERM U1116, Equipe 2, Faculté de Médecine, 54511 Vandoeuvre les, Nancy, France Full list of author information is available at the end of the article doses of catecholamines is a strategy to consider, albeit with many potential side effects such as tachyarrhythmia or myocardial cell damage [5]. The present study of Chawla and colleagues was designed to determine the appropriate dose of angiotensin II in the setting of distributive shock with high cardiac flow.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
